It happened between Horsham Road and County Line Road just before 11:30 a.m., according to officials.
A Peterbilt 4 car carrier was headed north on 202 when a southbound Toyota Rav4 crossed into the oncoming lane, police said. The truck hit the Toyota on the front driver's side corner.
The 50-year-old Toyota driver, a woman from King of Prussia, was ejected from her vehicle and pronounced dead at the scene, police said. An 86-year-old Ambler man in the passenger seat was extracted from the car and also pronounced dead.
The driver of the truck, a 44-year-old Levittown man, received minor injuries and was taken to Grand View Hospital, according to the release.
A stretch of Route 202 was shutdown Monday afternoon while crews worked the scene.
Witnesses are being asked to call the Montgomery Township Police Department’s Highway Safety Unit at 215-362-2301.
Click here to follow Daily Voice Lower Merion-Narberth and receive free news updates.